Reproduction Abstracts

The reproductive homeobox X-linked, Rhox, genes encode transcription factors that are expressed selectively in reproductive tissues. While there are 33 testis-expressed Rhox genes in mice, only Rhox5 and Rhox8 are produced by Sertoli cells, suggesting that they alone regulate somatic-cell gene products crucial for germ-cell development. We used the Rhox5 promoter to drive tissue-specific RNAi to knockdown (KD) RHOX8 in vivo...